Signal may send cancer’s cellular factories into overdrive
A network of signals active in almost all types of cancer sends the protein factories in our cells into overdrive, and may help fuel a tumour’s uncontrolled growth, new research suggests.
Scientists at The Institute of Cancer Research, one of the world’s most influential cancer research institutes, identified a molecular trigger responsible for ramping up activity of the endoplasmic reticulum (ER) – the cellular factory that makes the building blocks cancer cells need to keep growing.
The findings may help to explain how cancer cells maintain their high levels of metabolism – and could uncover future targets for cancer treatment
The top three images show human hepatocarcinoma cells with the endoplasmic reticulum (blue) and nucleus (red). Copyright: Dr Chris Bakal, The Institute of Cancer Research, London.
The bottom image shows human epithelial cells from breast tissue treated with Torin, an inhibitor of TOR kinase, where the endoplasmic reticulum is (green), nuclei (red) and F-actin (grey) Copyright: Dr Chris Bakal, The Institute of Cancer Research, London.
Read more: http://www.bbsrc.ac.uk/news/health/2014/140709-pr-signal-may-send-cancer-into-overdrive.aspx